About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

Overview

Targeted lipid nanoparticles (tLNPs) represent a key new modality to enablethe effectivedelivery of mRNA.ThetLNPchemistry, manufacturing, and control (CMC) team (TCT) is a newly formed group under Biologics CMC, Development Sciences, R&D. ThetLNPCMC team focuses on process development fortLNPs, including mRNA process development,tLNPprocess development, and formulation development.

The targeted lipid nanoparticle (tLNP) process development team isseekinga highly motivated, talented, and innovative scientist. This position will play a key role in advancingtLNPprograms by serving as a technical expert in targeting moiety conjugation technologies, including monoclonal antibodies (mAbs), Fabs, and related ligand formats. The successful candidate will partner with mRNA and LNP process development team members to design and implement robust strategies for commercial process development and process characterization. In addition, this individual will work cross-functionally with internal stakeholders and external partners to ensure right-first-time technology transfer of mRNA, LNP, and conjugation processes into AbbVie GMP manufacturing facilities.

Key Responsibilities

• Serve as a technical expert in conjugation technologies for linking targeting moieties such asmAbs, Fabs, and other ligands to lipid nanoparticles.
• Independently design, execute, and interpret critical laboratory experiments to build deep technical understanding of LNP conjugation, with emphasis on reaction kinetics, process optimization, and scalability to commercial manufacturing batch size.
• Operate with autonomy in laboratory research and methoddevelopment andproactivelyinitiatescientifically meaningful new areas of investigation that can be incorporated into development programs.
• Lead or contribute to the development of robust process strategies supporting commercial readiness for targeted LNP programs.
• Partner with mRNA and LNP process development colleagues, as well asPDS&T,todrive process characterizationand improve process understanding.
• Provide technical leadership for development, execution, and interpretation of experiments aimed atoptimizingprocess robustness, scalability, and manufacturability.
• Collaborate cross-functionally with key internal and external partners to enableright-first-time tech transferinto AbbVie GMP facilities.
• Identifytechnical risks and support mitigation strategies for targeted LNP, mRNA, and conjugation processes.
• Contribute to CMC planning, technical documentation, and cross-functional communication for program advancement.
• Stay current on emerging technologies, platforms, and best practices relevant to targeted LNP delivery and conjugation science.

• BS or equivalent education and extensive, typically 14+ years of experience; MS or equivalent education with typically 12+ years of experience; PhD with typically 6+ years of industry experience in area or scientific area of discipline.
• Demonstrated ability tooperateeffectively in a cross-functional, matrixed environment.
• Strong scientific judgment, problem-solving skills, and attention to detail.
• Excellent written and verbal communication skills.
• Experience supporting GMP manufacturing, process characterization, scale-up, or technology transfer is preferred.
• Strong background in biologics, nanoparticle systems, conjugation chemistry, process development, or related CMC disciplines.
• Previousdirect report management responsibilities are preferred.

Preferred Experience

• Hands-on experience with conjugation strategies for biologics or targeting ligands.
• Familiarity with LNP formulation, mRNA modalities, or advanced drug delivery systems.
• Experience contributing to commercial process development and/or process characterization.
• Hands-on experience with tangential flow filtration development in the lab and scale-up.
• Knowledge of GMP requirements and manufacturing tech transfer expectations.

Success Factors

• Establishes deep technical credibility in targeted LNP conjugation and process development.
• Provides strong scientific and technical leadership across programs and stakeholders.
• Drives practical, scalable solutions that support manufacturability and commercialization.
• Builds effective partnerships to enable seamless technologytransferinto AbbVie GMP facilities.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof thisposting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.

• This job is eligible toparticipatein our long-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission,incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's sole andabsolutediscretion unless anduntil paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

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